منابع مشابه
Knowing when to let go
uring meiosis I, some mechanism must allow homologous chromosomes to separate while keeping sister chromatids paired until meiosis II. How does a cell make this distinction? On page 219, Rogers et al. propose that in C. elegans the aurora-B kinase AIR-2 is largely responsible for ensuring that cohesion between chromosomes breaks down at the proper place and time. The authors also identified add...
متن کاملCohesin resolves to let go
or microtubule asters, just as with life in general, sometimes you get stuck in a corner. And, say Cendrine Faivre-Moskalenko and Marileen Dogterom (FOM Institute for Atomic and Molecular Physics, Amsterdam, Netherlands), it can take a catastrophe to get things moving again. Dogterom has been trying to reproduce aster behavior in the minimal environment of a microfabricated chamber. Her beads, ...
متن کاملCrossing over to let go
A function for multisite phosphorylation Many transcription factors are regulated by phosphorylation on multiple residues. Mylona et al. analyzed multisite phosphorylation in the transcription factor Elk-1 and showed that it may protect against excessive activation (see the Perspective by Whitmarsh and Davis). Phosphorylation by the kinase ERK2 occurred at eight sites, but the sites were phosph...
متن کاملIsotype controls--time to let go?
Keeney et al. (1) provide a graphic example of where isotype controls don’t work and can in fact lead to erroneous estimations of the target subpopulation. We would agree that for the accurate enumeration of CD34 positive stem cells, isotype controls are not always helpful and indeed there are other examples of rare event analysis where the isotype controls don’t work. We recognize therefore th...
متن کاملChromosome Segregation: Learning to Let Go
To ensure accurate chromosome segregation, cohesion between sister chromatids must be released in a controlled manner during mitosis. A new study reveals how distinct centromere populations of the cohesin protector Sgo1 are regulated by microtubule attachments, cyclin-dependent kinases, and the kinetochore kinase Bub1.
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ژورنال
عنوان ژورنال: Nature
سال: 2010
ISSN: 0028-0836,1476-4687
DOI: 10.1038/466284a